Sayari Bhattacharya

Doctoral Researcher in Computational Biophysics
Kolkata, India | sayaribhattacharya4@gmail.com | LinkedIn | GitHub Profile

Professional Summary

I am a doctoral researcher specializing in computational biophysics and data-driven molecular modeling. I orchestrate high-performance molecular dynamics simulations, statistical modeling, and extensive analytical pipelines to understand how proteins fold. I am highly experienced in deploying advanced sampling methods and employing rigorous dimensionality reduction frameworks to distill intricate, multi-dimensional physical landscapes into precise theoretical insights.

Technical Expertise

Computation
Python (NumPy, SciPy, Pandas), Artificial Intelligence Architectures (VAEs, CNN-VAE, TVAE), Linux Environments, Git Version Control
Simulation
GROMACS, Enhanced Sampling Regimes (Metadynamics, Replica Exchange, Umbrella Sampling), Conformational Navigation
Analytics
Dimensionality Reduction, Unsupervised Clustering, Markov State Models (MSMs), Rigorous Statistical Mechanics

Research & Investigations

Intrinsically Disordered Proteins & Amyloidosis Mechanisms
  • Led comprehensive mechanistic analyses delineating amyloid fibril elongation paradigms and structural polymorphic variance utilizing high-performance modeling.
  • Simulated natively disordered protein ensembles to architect theoretical transition maps, establishing robust connections between statistical physics and molecular biology.
Conformational Mapping & Kinetic Network Development
  • Designed algorithmic simulation pipelines to autonomously navigate rugged thermodynamic free energy boundaries, recovering mathematically rare macroscopic phenomena.
  • Engineered expansive kinetic equilibrium networks to formalize biomolecular metastable clustering operations across extended timescales.
Thermodynamic Landscape Benchmarking Pipeline
Biophysical Chemistry (2025)
  • Performed systematic evaluations of diverse dimensionality reduction architectures against classic native folding assemblies of the Trp-Cage mini-protein.
  • Created extensive automated mathematical processing suites leveraging SciPy data structures to synthesize complex continuous structural coordinate pipelines.
Enhanced Sampling Paradigms in Fibrillar Complexes
Jan 2023 - May 2023
  • Calculated deep thermodynamic stabilization energies inherent to early-stage Amyloid formation sequences through intensive Metadynamics applications.

Academic Background

Master of Science, Physics
2021 - 2023
S.N. Bose National Centre for Basic Sciences
Graduated with Distinction (86%) | Rank: 3rd in academic cohort.
Bachelor of Science, Physics
2018 - 2021
Jadavpur University
CGPA: 8.77 (81.67%) | Rank: Top 10 in University.

Honors & Distinctions

  • GATE Examination (2023) Qualified — Prestigious national comparative evaluation in comprehensive Physics.
  • JAM & JEST (2021) Qualified — Selective Indian national science entrance examinations.
  • DST INSPIRE SHE Fellowship — Granted exclusively to the top 1% of science undergraduates continuously executing nationwide.
  • JBNSTS Exigency Senior Scholar — Elevated placement amongst fifty premier scientific candidates across West Bengal.
  • Best Student Distinction (2016) — Commended for extreme academic aptitude spanning the West Bengal 10th Board evaluation systems.